@article {852, title = {Phytochemical, in vitro Antioxidant and in vivo Safety Evaluation of Leaf Extracts of Tragia plukenetii}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {338-345}, type = {Original Article}, chapter = {338}, abstract = {

Objective: To investigate the phytochemical properties, in vitro antioxidant and in vivo safety profile of leaf extracts of Tragia plukenetii (TP). Methods: TP leaves were obtained from the south part of India (Guntur District, Andhra Pradesh) and it was extracted with different solvents (benzene extract (BE), chloroform extract (CE) and methanolic extract (ME)). These TP extracts were analyzed for the in vitro antioxidant activity by DPPH reducing power, β-carotene-linoleic acid complex and iron chelation assays followed by in vivo acute oral and dermal toxicities using Swiss mice and Wistar rats respectively. Results: The present study results revealed ME exhibited an effective and powerful antioxidant activity when compared to a standard antioxidant, butylated hydroxytoluene (BHT). ME was found to be effective in DPPH, β-carotene-linoleic acid complex and iron chelation assays respectively. In vivo acute oral toxicity study revealed that mice treated with up to 5000 mg/kg of BE, CE and ME did not show any signs of toxicity. Furthermore, similarly, acute dermal toxicity study demonstrated that BE, CE and ME did not exhibit any signs of dermal toxicity up to 1000 mg/kg in rats. Conclusion: TP extracts possess an excellent antioxidant activity with a devoid of any signs of acute oral and dermal toxicities.

}, keywords = {Dermal toxicity, DPPH assay, Iron chelation, Oral toxicity, Tragia plukenetii., β-carotene-linoleic acid complex}, doi = {10.5530/pj.2019.11.50}, author = {Srinivasa Reddy Bonam and Sathish Kumar Manoharan and Vijayapandi Pandy and Anji Reddy Raya and Rama Rao Nadendla and Manjunathan Jagadeesan and Ankem Narendra Babu} } @article {926, title = {Phytochemical, in vitro Antioxidant and in vivo Safety Evaluation of Leaf Extracts of Tragia plukenetii}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {July 2019}, pages = {848}, type = {Corrigendum}, chapter = {848}, abstract = {

In principle, this figure represents non-toxic effect of TP. As all the treatment groups are non-toxic, we have optimistically represented the figure. Due to the manual error while copying the figure 4, BE image was taken from different group instead of actual one. This has been rectified in the corrected image of figure 4. In ground reality, however, the present modifications in the figure do not alter the scientific meaning of the figure or the outcome of the study conclusions. Read more...

}, keywords = {Nil}, author = {Srinivasa Reddy Bonam and Sathish Kumar Manoharan and Vijayapandi Pandy and Anji Reddy Raya and Rama Rao Nadendla and Manjunathan Jagadeesan and Ankem Narendra Babu} }