@article {765, title = {Pharmacological Evaluation of Bacopa monnieri Extract against Depressive like Behavior Induced by Ethanol Withdrawal in Rats}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {November 2018}, pages = {s48-s53}, type = {Research Article}, chapter = {s48}, abstract = {

Background: Alcohol withdrawal syndrome lead to relapse to alcohol use and depression is the most common symptom of withdrawal. Bacopa monnieri is a traditional memory enhancer and has reported antidepressant properties as well. Objective: The present study was designed to evaluate the protective effects of Bacopa monnieri extract in alcohol withdrawal depressive-like behavior in alcohol-dependent rats. Methods: Plant drug was extracted with ethanol (70\% v/v) using soxhlet extraction. Ethanol 7.2\%, v/v was given to the rats in a liquid diet for 21 days and then was withdrawn from the diet and animals were observed at 6th and 24th h for withdrawal signs like depressive behavior and locomotor hyperactivity. Results: The phytochemical testing of extract revealed the presence of flavonoids, alkaloids, steroids, and tannins. Bacopa monnieri extract (100, 200 and 300 mg/kg, oral) and fluoxetine (10 mg/kg i.p) treatment at the 6th and 24th h of ethanol withdrawal produced the significant (p\<0.001) decrease in the immobility time as compared to the disease control rats when tested on forced swim test and tail suspension test. Bacopa monnieri extract and fluoxetine treatment produced significant (p\<0.001) inhibitory effects on locomotor hyperactivity as well. Histopathological examination did not show any remarkable pathological and microscopic changes. Conclusion: Findings from the present study showed that Bacopa monnieri extract treatment has beneficial effects on ethanol withdrawal depressive-like behavior in rats.

}, keywords = {Bacopa monnieri, Depression, Ethanol withdrawal syndrome, Histopathology, Locomotor hyperactivity}, doi = {10.5530/pj.2018.6s.9}, author = {Lalit Sharma and Aditi Sharma and Girdhari Lal Gupta and Gopal Singh Bisht} } @article {636, title = {A Review on Himalayan Pine Species: Ethnopharmacological, Phytochemical and Pharmacological Aspects}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {June 2018}, pages = {611-619}, type = {Review Article}, chapter = {611}, abstract = {

Introduction: Ever since ancient times, medicinal plants recognized as major source of therapeutics, as rescue for human diseases and maintain health. There is an exponential increase in usage of green medicines due to less cost and fewer side effects. The family Pinaceae, is largest conifer in species diversity. Pinus is the largest genus of monoecious, resiniferous, evergreen trees commonly known as Pines. Three species of pines occur wild in Indian Himalayas Pinus roxburghii, Pinus wallichiana , Pinus gerardiana. In addition, the constituents present in these plants are beneficial for the purpose of treatment of various ailments. Methods: Information was collected from scientific journals, books, and reports via electronic search tools( Medline, Pubmed etc.) Results: This review summarizes the existing information on three species of Pinus in relation to their pharmacognostic properties, phytochemistry, ethanopharmacology and pharmacological activities.

}, keywords = {Ethanopharmacology, Himalayas, Pharmacology, Phytochemistry, Pinus, Pinus gerardiana, Pinus roxburghii, Pinus wallichina}, doi = {10.5530/pj.2018.4.100}, url = {http://fulltxt.org/article/678}, author = {Aditi Sharma and Lalit Sharma and Rohit Goyal} }