@article {428, title = {Determination of Antipyretic and Antioxidant Activity of Cassia occidentalis Linn Methanolic Seed Extract}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {913-916}, type = {Original Article}, chapter = {913}, abstract = {

Objective: To perform the pharmacognostical screening and determination of antipyretic and antioxidant activity of Cassia occidentalis L. Methanolic seed extract by different in-vitro models. Methods: The different pharmacognostical parameters were evaluated as per standard procedure. Finally, antipyretic (Brewer\’s Yeast Pyrexia model) and antioxidant activity (DPPH and Hydrogen Pyrode Method) was evaluated by adopting different methods. Results: The extracts showed a marked antipyretic effect (Figure 1) by causing a reduction in yeast-induced fever. Methanolic extract (400 mg/kg) showed the effect to the same degree as paracetamol (20 mg/kg, i.p.). The experimentally induced laboratory model was employed in evaluating the antipyretic activities of methanolic extracts of Cassia occidentalis L. The extract caused a better hypothermal activity against yeast-induced pyrexia in rats. Free radical scavenging activity of Cassia occidentalis L. was found because polyphenolic compounds present in plant contribute significantly to the total antioxidant capacity of the seed. Flavonoids play some important pharmacological roles against diseases, such as cardiovascular diseases, cancer, inflammation and allergy. Conclusion: The results of the study indicate that the methanolic seed extract of Cassia occidentalis L. possesses strong antipyretic and antioxidant activity. This study described many pharmacognostical features and antioxidant activity of seeds of Cassia occidentalis L. which will give a new direction for the future scientific research.

}, keywords = {Antioxidant., Antipyretic, Cassia occidentalis L., Pharmacological, Phytochemical}, doi = {10.5530/pj.2017.6.143}, url = {http://fulltxt.org/article/196}, author = {Vijay Vikram Singh and Jainendra Jain and Arun Kumar Mishra} } @article {331, title = {Pharmacognostical and Physicochemical Analysis of Cleome viscosa L. Seeds}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {April 2017 }, pages = {372-377}, type = {Original Article}, chapter = {372}, abstract = {

Aim: The seeds of Cleome viscosa L. are used to treat tumor, emesis, diarrhea, epilepsy and hyperthermia. Seeds are used to heal wound also. In order to ensure the use of only genuine and uniform material in treatment of ailments by herbs and herbal formulations, pharmacognostical standardization and physiochemical parameters evaluation is needed. Methods: Morphological and powder microscopic characters of seed powder were studied. The physiochemical parameters studied were LOD, total ash, acid insoluble, water soluble, sulphated ash, extractives, volatile oil content and crude fibre content etc. Further, florescence analysis and element analysis of seed powder was performed by undergoing chemical reaction +UV method and EDAX method respectively. Results: Brown colored seeds with rough seed surface with seed size 0.1 cm were recorded. The pods were brown coloured when air dried. They were 4-5 cm long containing 8-12 small seeds. Powder microscopic study revealed the presence of fragment of epidermis of testa, groups of cells resembling like stone cells and irregularly shaped protein bodies were observed. Florescence Analysis revealed the presence of chromophores. EDAX analysis showed the presence of Mg, Al, Si, S, Cl, K, Ca and Cu etc in different amount. Conclusion: Pharmacognostical and physiochemical parameters were established which would facilitate quick identification and selection of the herbal drugs from various adulterants.

}, keywords = {Cleome viscosa L., Crude fibre, Macroscopic, Microscopic, Physicochemical}, doi = {10.5530/pj.2017.3.63}, url = {/files/PJ-9-3/10.5530pj.2017.3.63}, author = {Harpreet Singh and Amrita Mishra and Arun Kumar Mishra} } @article {132, title = {Hepatoprotective effect of Prunus armeniaca L. (Apricot) leaf extracts on Paracetamol induced liver damage in Wistar rats}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {December 2015}, pages = {154-158}, type = {Original Article}, chapter = {154}, abstract = {

Objective: To evaluate the hepatoprotective effect of Prunus armeniaca L. (Apricot) leaf on paracetamol induced liver toxicity in rats. Method: Phytochemical investigation was performed to find active constituents of the plant extracts by the different phytochemical tests. After induction of liver toxicity, the biochemical parameters such as serum glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT), serum alkaline phosphatase (sALP), serum bilirubin (SB), thiobarbituric acid reactive substances (TBARS), \γ-glutamyl transferase (GGT), lactate dehydrogenase (LDH), total protein (TP), albumin. The physical parameters including liver weight, body weight and histopathological changes in the liver were studied with Ursodeoxycholic acid as standard hepatoprotective agents. Results: The phytochemical investigation of the extracts showed the presence of Alkaloids, volatile oil, saponin glycosides, condensed tanins, terpenoids, steroids and flavonoids. Methanol and aqueous extract before the paracetamol administration caused a significant reduction in the values of sGOT, sGPT, sALP, TBARS, GGT, LDH TP, Albumin and sB (P\<0.01) almost comparable to the Ursodeoxycholic acid. The hepatoprotective activity was confirmed by histopathological examination of the liver tissue of control and treated animals. Conclusions: The result concludes that Prunus armeniaca L. possesses the hepatoprotective effect against paracetamol induced liver toxicity in rats.

}, keywords = {Apricot, Hepatotoxicity, Liver toxicity., Paracetamol}, doi = {10.5530/pj.2016.2.9}, author = {Varsha Raj and Arun Kumar Mishra and Amrita Mishra and Najam Ali Khan} } @article {65, title = {Cleome viscosa Linn (Capparaceae): A Review}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {Nov-Dec 2015}, pages = {326-329}, type = {Review Article}, chapter = {326}, abstract = {

Cleome viscosa Linn. (Capparaceae) called as \“Hurhur\” is an annual, sticky herb found in plains of India, Africa, and Pakistan etc as a common weed. Plant and its parts (leaves, seeds, roots etc.) are used traditionally to cure variety of diseases. Traditionally the plant possess anthelmintic, carminative, anticonvulsant, antidiarhhoeal, antimicrobial, wound healing properties. The review shows that various phytochemical compound were isolated from whole plant and its parts (seeds, leaves, roots etc.). The review reveals the collection of important pharmacological activites like antimicrobial, analgesic, antiemetic, antidiarrhoeal, hepatoprotective, antifibrotic, antitumor, anticonvulsant and psychopharmacological. It also made emphasis on its application in biodiesel formation. The review draws attention towards the traditional, phytochemical and pharmacological knowledge accessible on Cleome viscosa Linn. which would be beneficial for researchers to discover novel chemical entities.

}, keywords = {Anticonvulsant, Biodiesel, Cleome viscosa Linn., Cleomiscosin, Phytochemical, Psychopharmacological}, doi = {10.5530/pj.2015.6.1}, author = {Harpreet Singh and Amrita Mishra and Arun Kumar Mishra} }