@article {485, title = {Nephroprotective Activity of Methanolic Extract of Lantana camara and Squash (Cucurbita pepo) on Cisplatin-Induced Nephrotoxicity in Rats and Identification of Certain Chemical Constituents of Lantana camara by HPLC-ESI- MS}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {December 2017}, pages = {136-147}, type = {Original Article}, chapter = {136}, abstract = {

Introduction: Cisplatin is a highly effective chemotherapeutic agent; its clinical use is severely limited by serious side effects as nephrotoxicity. The aim of this study is to evaluate the nephroprotective activity of defatted methanolic extract of two Egyptian plants: Lantana camara and Cucurbita pepo and certain fractions derived from the defatted methanolic extract of L. camara on cisplatin-induced nephrotoxicity in rats. Also, identification of certain chemical constituents of L. camara by HPLC-ESI- MS. Methods: Nephrotoxicity was induced in rats by single dose of cisplatin. The effect of plants extract at doses 100-400 mg/kg.b.wt comparing with standard; ascorbic acid; was determined using serum urea, creatinine and some ions. Furthermore, the effect of these extracts on some renal antioxidant enzymes and histopathological examination of kidneys were examined. Results: The defatted methanolic extract and ethyl acetate fraction of L. camara showed the highest improvement of renal parameters. Also, HPLC-ESI-MS analysis of L. camara extracts exhibited bioactive phenolic compounds including phenyl ethanoid, flavonoids and phenolic acids. Conclusion: The phytochemical constituents of L. camara are responsible for their nephroprotective activity.

}, keywords = {Antioxidant enzymes, Ascorbic acid, Creatinine, Flavonoids, Histological studies, Phenyl etanoid.}, doi = {10.5530/pj.2018.1.24}, url = {http://fulltxt.org/article/410}, author = {Heba Abdel-Hady and Mortada Mohamed El-Sayed and Afaf Ahmed Abdel-Hady and Maher Mahmoud Hashash and Ahmed Mohamed Abdel-Hady and Tarek Aboushousha and El-Sayed Saleh Abdel-Hameed and Ezzat El-Sayed Abdel- Lateef and Eman Abdalla Morsi} }