@article {760, title = {Phytochemical Screening, LC-MS Studies and Antidiabetic Potential of Methanol Extracts of Seed Shells of Archidendron bubalinum (Jack) I.C. Nielson (Julang Jaling) from Lampung, Indonesia}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {November 2018}, pages = {s77-s82}, type = {Original Article}, chapter = {s77}, abstract = {

Background: Some Malaysia and Indonesia people believed that root and seed shell of Archidendron bubalinum can treat diabetes. However, seed shell of Archidendron bubalinum has not yet to be scientifically proven and confirmed their ability to treat diabetes. The study of the potential of this seed shell was also scarcely available. Objective: The recent work was aimed to investigate the phytochemical screening of methanol extracts of seed shells of Archidendron bubalinum and to evaluate their chemical compositions and antidiabetic activities. Material and Methods: The methods of phytochemical screening were including alkaloids, flavonoids, tannins, polyphenols, saponins, and terpenoids. Their chemical compositions were determined by Liquid Chromatography-Mass Spectrometry (LC-MS) and antidiabetic activities were performed by \α-glucosidase inhibitory method. Results: The phytochemical screening showed that methanol extracts of seed shells of Archidendron bubalinum contain flavonoids, tannins, polyphenols, and terpenoids. This extracts exhibited antidiabetic activity with IC50 7.77 \μg/mL. This result was supported by LC-MS analysis which showed the presence of phlorizin and astilbin, in which these compounds had high inhibitory activity against \α-glucosidase or diabetes. Conclusion: LC-MS analysis revealed the presence of polyphenol compounds namely phlorizin and astilbin in which had high \α-glucosidase inhibitory activity, might largely contribute in the antidiabetic activity. Key words: Phytochemical screening, Mass spectrometry

}, keywords = {Anti-diabetic, Archidendron bubalinum, Mass spectrometry, Phytochemical screening}, doi = {10.5530/pj.2018.6s.15}, author = {Hanafi and Candra Irawan and Henny Rochaeni and Lilis Sulistiawaty and Achmad Nandang Roziafanto and Supriyono} } @article {476, title = {Volatile Compound Analysis using GC-MS, Phytochemical Screening and Antioxidant Activities of the Husk of {\textquotedblleft}Julang-Jaling{\textquotedblright} (Archidendron bubalinum (Jack) I.C Nielsen) from Lampung, Indonesia}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {December 2017}, pages = {92-98}, type = {Original Article}, chapter = {92}, abstract = {

Background: \“Julang-jaling\” (Archidendron bubalinum (Jack) I.C Nielsen) fruits are commonly used as traditional food and in the treatment of blood sugar and heart disease. However, the research about the phytochemicals of the parts of this plants and their bioactivity was rare. Objective: The recent study was aimed to analyze volatile compounds in the extract of \“julang-jaling\” husks and evaluate their antioxidant and antimicrobial activities. Material and methods: The extraction was conducted using n-hexane, ethyl acetate, and methanol as extracting agent. The phytochemical assay was performed for all extracts, and followed by volatile compound analysis using GC-MS. The antioxidant assay was performed using DPPH method, and the antimicrobial activity was conducted using agar disc diffusion method. Results: The phytochemical assay showed that all extracts of \“julang-jaling\” husks contain various phytoconstituents having potential bioactivity. All extracts exhibit antioxidant activity with different level of activity depend on the type of extract. The IC50 value were 273.57 ppm, 324.913 ppm, 735 ppm, for ethyl acetate, methanol and n-hexane, respectively. All extracts were able to inhibit the growth of Bacillus cereus, with the highest antimicrobial activity was gained for ethyl acetate extract. Both ethyl acetate and methanolic extract have antimicrobial activity toward E. coli, but no extracts yield positive results for Aspergillus flavus and Aspergillus niger. Conclusion: GC-MS analysis revealed the presence of hexadecanoic acids and their ester form in all extract, which might largely contribute in the antioxidant and antimicrobial activity.

}, keywords = {Antimicrobial activity, Antioxidant, Archidendron bubalinum (Jack) I.C Nielsen, GC-MS, Phytochemicals}, doi = {10.5530/pj.2018.1.17}, url = {http://fulltxt.org/article/403}, author = {Candra Irawan and Foliatini and Hanafi and Lilis Sulistiawaty and Maman Sukiman} }