@article {581, title = {Anti-Diabetic, Anti-Oxidant and Anti-Adipogenic Potential of Quercetin Rich Ethyl Acetate Fraction of Prunus persica}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {March 2018}, pages = {463-469}, type = {Original Article}, chapter = {463}, abstract = {

Background: Diabetes mellitus is enfeebling threatening diseases with continuously increasing rates of incidence and mortality and it may rise tremendously by 2025. Objective: Quercetin rich ethyl acetate fraction (PP-EtOA) of leaves of Prunus persica was evaluated for antidiabetic, anti-oxidant and anti-adipogenic activities. Material and Methods: Streptozotocin (STZ)-induced diabetic rat model, oral glucose tolerance test (OGTT) and normalglycemic rat models were investigated at the doseof 100 and 200 mg/kg,p.o. of PP-EtOA. Results: At 200 mg/kg, significant anti-hyperglycaemic activity(p\<0.05) was observed in all the rat models. In STZ induced diabetic rat model, improvement in body weight and lipid profile was also observed.DPPH (2,2\’-diphenyl-1-picrylhydrazyl) free radical scavenging method showed dose dependent scavenging. Preadipocyte differentiation assay (3T3-L1) showed significant inhibition of differentiation. HPLC fingerprinting analysis of fraction was also performed. Conclusion: PP-EtOA possesses potent free radical scavenging property. Its antihyperglycemic and antiadipogenic activities may be due to quercetin (flavonoid) and may prove to be effective in the treatment of diabetes mellitus and diabetes driven dyslipidemic conditions.

}, keywords = {Anti-adipogenic, Anti-diabetic, Anti-oxidant, Prunus persica, Quercetin}, doi = {10.5530/pj.2018.3.76}, url = {http://fulltxt.org/article/509}, author = {Gaurav Sharma and Sunil Kumar and Megha Sharma and Navneet Upadhyay and Sunil Kumar and Zabeer Ahmed and Neeraj Mahindroo} } @article {408, title = {Immunomodulatory Activity of Bioactive Fraction (PBC) from Phyllostachys bambusoides}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {786-791}, type = {Original Article}, chapter = {786}, abstract = {

Background: The lack of vaccines and limitations of currently available strategies demand a need to develop safe and efficacious immunomodulators. Phyllostachys bambusoides is traditionally used for various autoimmune and infectious disorders, a property possibly attributable to presence of flavonoids like orientin and iso-orientin. Objective: the objective of this study was, to search a potent immunomodulator which elicit both Th1 and Th2 immune response. Methods: The animals were (Balb/c) treated with the bioactive fraction (PBC) from P. bambusoides (100 and 200 mg/kg body weight) for 14 days with SRBC (Sheep Red Blood Cells) as an antigen. Haemagglutination antibody (HA) titre, delayed type hypersensitivity (DTH) reaction, phagocytic index, NO production, analysis of cytokines in serum and CD80/ CD86 population in spleen. Results: PBC significantly enhanced the expression of IgM and IgG titre and DTH response in a dose dependant manner after 24 and 48 h in BALB/c mice with a maximum response at 200 mg/Kg. Besides humoral and cell mediated immunity, it also enhanced phagocytic index, nitric oxide production, which further leads to protection against Candida albicans infection. It also, enhanced the expression of CD80 and CD86 in splenic cells. Conclusion: Taken together these in vitro and in vivo data, our results suggest that PBC acts as an effective immunostimulator which specially enhances macrophage function during infection. This further supports the role of PBC in immunopharmacologic applications.

}, keywords = {Cytokine., Ha Titre, Immunostimulation, Macrophages, Phyllostachys Bambusoides}, doi = {10.5530/pj.2017.6.123}, url = {http://fulltxt.org/article/176}, author = {Sunil Kumar and Gaurav Sharma and Amit Kumar} } @article {409, title = {To Evaluate the Antidiabetic and Rejuvenating Capability of Tissues on Alloxan Induced Diabetic Rats under the Effect of Ethanolic Leaf Extract of Coriandrum sativum: A Histopathological Study}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {792-798}, type = {Original Article}, chapter = {792}, abstract = {

Objective: To evaluate the antidiabetic and rejuvenating capability of tissues on alloxan induced diabetic rats under the effect of ethanolic leaf extract of Coriandrum sativum. Methods: Diabetic model was prepared by administration of alloxan monohydrate (150 mg/ kg i.p). The ethanolic leaf extracts of Coriandrum sativum at a dose of 200 and 400 mg/kg of body weight were administrated to diabetic induced groups for a period of 28 days. The effect of ethanolic leaf extract of Coriandrum sativum leaf extract on serum blood glucose, insulin, lipase, \α- amylase and LDH as well as kidney function test [urea, uric acid, albumin, protein and creatinine] were measured in the alloxan induced diabetic rats. Results: In the acute toxicity study, ethanolic leaf extract of Coriandrum sativum leaf was non-toxic at 2 000 mg/kg in rats. The increased insulin level, albumin and protein level, decreased blood glucose and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of Coriandrum sativum leaf compared to diabetic control rats. In Histopathological study were revealed toward normal. Conclusion: Ethanolic extract of Coriandrum sativum leaf possesses significant antidiabetic and rejuvenating capability of tissues.

}, keywords = {Alloxan, Coriandrum sativum., Pancreas and Kidney Tissue, Wistar Rats}, doi = {10.5530/pj.2017.6.124}, url = {http://fulltxt.org/article/177}, author = {Bhaskar Sharma and Gaurav Sharma and Suresh Chand Joshi and Sunil Kumar Singh} }