@article {396, title = {Alkaloid from Phoebe declinata Nees Leaves}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {713-720}, type = {Original Article}, chapter = {713}, abstract = {

Introduction: Genus Phoebe have been reported to produce isoquinoline alkaloids as aporphines, noraporphines, and benzylisoquinolines. Many of these isolates exhibit diversified biological activities, including cytotoxic activity. Objective: The objective of this study is to determine cytotoxic activity of compound isolated from Phoebe declinata againts MCF-7 (breast cancer cell line). Methods: Extraction was done by reflux using n-hexane, antioxidant activity measured by DPPH method and reducing power method, cytotoxic activity measured by MTT assay using MCF-7 cell line, struture eucidation was confirmed by NMR. Results: The antioxidant activity measured using DPPH method for 1 and 2 showed IC50 value of 6.42 and 11.80 \μg/mL respectively and using reducing power method for 1 and 2 showed IC50 value of 7.02 and 13.74 \μg/mL respectively. Compound (1) and (2) exhibited cytotoxic activity against MCF-7 cells with an IC50 value of 82.978 and 93.179 \μg/mL. Conclusion: Compound (1) and (2) exhibited antioxidant activity and cytotoxic activity against MCF-7.

}, keywords = {Alkaloid, antioxidant activity, Cytotoxic activity, DPPH, MCF-7 cell line., Phoebe declinata nees}, doi = {10.5530/pj.2017.6.112}, url = {http://fulltxt.org/article/165}, author = {Berna Elya and Basah Katrin and Roshamur Cahyan Forestrania and Rosmalena Sofyan and Ryan Adi Chandra} }