@article {252, title = {Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {February 2017}, pages = {204-207}, type = {Original Article}, chapter = {204}, abstract = {

Aim: The present study was designed to examine the cytotoxic effects of ethanolic leaf extract of Caralluma fimbriata in the COLO 320 cell line. Materials and Method: The anti-proliferative effects were evaluated using the MTT assay. The COLO 320 cells were treated with different concentrations of the leaf extract of Caralluma (100 \– 300 \μg/ml) for 24 h. The cell viability and IC50 was calculated from the cytotoxicity. The morphology of the Caralluma treated cells, control, and positive control were observed under reverse phase inverted microscope. Result: The C. fimbriata ethanolic leaf extract showed dose dependant increase in cytotoxicity in COLO 320 human colon cancer cells. The maximum cytotoxic effect was noticed with maximum dose used in this study i.e., 300 g with an IC50 value of 233.87 g. Conclusion: The present study shows that the ethanolic leaf extract of Caralluma fimbriata is capable of reducing cell proliferation by inducing cytotoxicity of COLO 320 cells.

}, keywords = {Caralluma fimbriata, COLO 320 cell line, Colonic cancer, Cytotoxicity, MTT Assay}, doi = {10.5530/pj.2017.2.34}, url = {http://phcogj.com/fulltext/301}, author = {Shenai Ashwini and Devaraj Ezhilarasan and Roy Anitha} }