@article {2512, title = {Formulation Strategy and Excipient Selection for Tribulus terrestris L. Tablets: A Quality-Based Approach}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {June 2025}, pages = {370-377}, type = {Research Article}, chapter = {370}, abstract = {

Background: To develop and evaluate a tablet formulation containing standardized dry extract of Tribulus terrestris L.{\textemdash}a plant traditionally used in Mongolian medicine{\textemdash}by focusing on excipient optimization and pharmaceutical quality assessment. Methods: Tablets were manufactured using the wet granulation method, incorporating an extract standardized to 54.45\% dioscin. Various excipient ratios were investigated to determine the optimal formulation. Dioscin content was quantified using UV-visible spectrophotometry. Results: The optimized formulation comprised 25\% dry extract, 34\% lactose, 34\% microcrystalline cellulose, 6\% PVPP, 0.5\% magnesium stearate, 0.5\% talc, and 4.5\% HPMC. The tablets demonstrated acceptable pharmaceutical characteristics, including an average weight of 0.113 {\textpm} 0.001 g, hardness of 0.83 {\textpm} 0.23 MPa, friability of 98.17 {\textpm} 0.65\%, and disintegration time of 7.30 minutes. The dioscin content was 13.50 {\textpm} 0.50 mg/g, with an assay recovery of 95.51\%. Dissolution exceeded 83\% in both media within 45 minutes. The similarity factor (f$_{2}$) confirmed equivalent dissolution profiles. Conclusion: The developed T. terrestris tablet formulation met pharmacopoeial standards and exhibited consistent physical, chemical, and biopharmaceutical performance, supporting its potential as a standardized herbal medicinal product for clinical and commercial application.

}, keywords = {Tribulus Terrestre{\textquoteright}s L.; tablet; excipients; saponins; spectrophotometer}, doi = {10.5530/pj.2025.17.46}, author = {Baigalmaa Dovchinsuren and Wang Qin Hu and Jambaninj Dambiinyam and Yerkyebulan Mukhtar and Davaadagva Damdinjav and Enkhjargal Dorjbal} }