@article {1785, title = {Coleus atropurpureus (L) Benth. Leaves as a New Promising Drug for Abscesses Caused by Methicillin-resistant Staphylococcus aureus and Staphylococcus aureus}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {April 2022}, pages = {439-443}, type = {Research Article }, chapter = {439}, abstract = {

Background and Objective: Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) can cause an abscess, a skin condition with a build-up of pus due to a fluid or pus-filled tissue covering. This study aimed to determine the antibacterial activity of the ethanolic extract and its fraction from jawer kotok (Indonesian), Coleus atropurpureus (L) Benth.) against abscess-causing bacteria, S. aureus and MRSA. Materials and Methods: Laboratory Experimental Design. C. atropurpureus was collected, macerated using 96\% ethanol extract, then fractionated using ethyl acetate and n-hexane. Antibacterial properties of ethanol extract and its fraction using S. aureus ATTC 25923 and MRSA. Statistical analysis used: descriptive statistics. Results: It was found that the MIC values for S. aureus ATTC 25923 and MRSA were in the range of 0.78\% - 1.56\% w/v and the MBC value for the two test bacteria was 1.56\% Conclusions: Ethanol extract and n.hexane fraction from C. atropurpureus were new drugs for abscess treatment. It is necessary to research the formulation and evaluation of the ethanolic extract and the n-hexane fraction from C. atropurpureus against the two bacteria that cause abscesses first.

}, keywords = {Antibacterial, Coleus atropurpureus (L) Benth., Maceration, Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus ATTC 25923}, doi = {10.5530/pj.2022.14.56}, author = {Resmi Mustarichie and Yoppi Iskandar and Nyi Mekar Saptarini} }