Preparation and Evaluation of Cordia Fruit Gum as Tablet Binder

Preparation and Evaluation of Cordia Fruit Gum as Tablet Binder

Order of Publishing in Issue:

Volume :1

Issue :2

September, 2009

Authors:

Patil D.N.[1]*, Kulkarni A.R.[2], Hatapakki B.C.[1] and Patil B.S. [3]

Address:

[1] Department of Pharmacognosy & Phytochemistry, K.L.E.S’s, College of Pharmacy, Gadag - 582101., Karnataka (India) [2] Department of Pharmacology, K.L.E.S’s, College of Pharmacy, Belgaum-590041. Karnataka (India) [3] Department of Pharmacognosy, SET’s, College of Pharmacy, Dharwad. Karnataka (India)

Email-ID:

dnpatilgadag@rediffmail.com

Abstract: In the present work, we have formulated the oral tablets of paracetamol by using cordial fruit gum as a binder. The four different tablet formulations were prepared by wet granulation method. The binder concentrations used in the formulation were 2, 4, 6 & 8 % w/w. The evaluation of granules showed 0.643 to 0.746 mm granule size, 26.65 to 32.10 ° angles of repose and 21.8 to 13.4 % fines. Tablets were compressed to hardness at about 7.5 to 8.2 kg/cm2. The evaluation of tablet showed 1.58 to 1.10 % friability, 12 to 22 min disintegration time and more than 90 % dissolution in 75 min. Tablets at 6 % w/w binder concentration showed more optimum results as tablet binder. The cordial fruit gum was found to be useful for the preparation of uncoated tablet

Previous article in this issue: Determination of Protocatechuic Acid by HPTLC Method in Amomum subulatum Roxb. Fruit Extracts
Next article in this issue: A survey on knowledge and attitude of pharmacy, health science and medical students towards traditional medicine as well as willingness of students and doctors towards the integration of traditional and modern medicine in Gondar university.

Keywords:

Cordia fruit gum, Binder, Paracetamol and Dissolution

| Tags: Pharmacognosy Journal

Preparation and Evaluation of Cordia Fruit Gum as Tablet Binder

[Phcog J]

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