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Pharmacognostical, phytochemical screening and acute toxicity study of Crateva nurvala stem bark

Order of Publishing in Issue: 
9
Volume :1
Issue :2
September, 2009
Authors: 
Sikarwar Mukesh S.[1*], Patil M.B.[1], Kokate C.K.[2], Sharma Shalini [3], Bhat Vishnu[1]
Address: 
[1] K. L. E. S College of Pharmacy, Ankola, Karnataka, India [2] Vice Chancellor, K L E University, Belgaum, Karnataka, India [3] Dhanwantari Ayurveda Medical College, Hospital & Research centre, Siddapur, Karnataka

ABSTRACT: The aim of this research was to study the pharmacognostic, phytochemical parameters & acute toxicity of Crateva nurvala stem bark (family: Capparidaceae). Its stem bark was extracted with non-polar and polar solvents by simple maceration method.TLC were also carried out to identify the chief chemical constituent. The acute toxicity study of these extracts was also carried out in female albino rats (50mg to 5000 mg/kg body weight) as per OECD guidelines. Macroscopic study showed that it was yellowish brown powder with slight characteristic smell and bitter taste. Powder microscopy showed the presence of collenchyma, starch grains, pericyclic fibres, cork cells, stone cells, calcium oxalate crystals and phloem fibres. Phytochemical screening reported the presence of triterpenoids, Flavonoids, tannins & steroidal compounds. In the acute toxicity study, oral administration of 5g/kg of Crateva nurvala stem bark various extracts produced neither mortality nor changes in behaviour or any other physiological activities.

Keywords: 
Crateva nurvala, phytochemical, microscopy, acute toxicity.
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