Abstract:

Objective: The study was undertaken to evaluate the antioxidant activity of fruits of Trichosanthes dioica (Cucurbitaceae) and compared with ascorbic acid (Standard). Materials and Methods: Anti-oxidant activity of aqueous extract of Trichosanthes dioica (TSD) fruits was studied for its free radical scavenging property in different in vitro methods as 1, 1 diphenyl-2- picryl hydrazyl, nitric oxide, reducing power assay and hydrogen peroxide radical method. Different concentrations of aqueous extract of TSD were prepared and evaluated by standard methods. Results: The IC50 values of aqueous extract of TSD were compared with ascorbic acid (Standard) and it was noted that, the extract showed significant concentration dependent free radical scavenging property in all the methods. Conclusion: Results from the study showed that aqueous extract of TSD possess in vitro free radical scavenging activity. The findings could justify the inclusion of this plant in the management of antioxidant activity.