The present study was designed to investigate the anti-inflammatory activity of the water extract of Argyreia nervosa. Inflammatory diseases including different types of rheumatic diseases are very common throughout the world. Therefore the search for a better tolerated anti-inflammatory agent appears to be a necessity. Argyreia nervosa is used as a folk medicine for the treatment of inflammation in India. Present study revealed that the plant Argyreia nervosa possesses a significant anti-inflammatory activity as evidencesd in carrageenan induced paw edema method, which supports the folkloric claim of the anti-inflammatory activity of the plant. Our finding supports the reported therapeutic use of herb Argyreia nervosa in tribal medicine for the treatment of inflammation.