TY - JOUR T1 - Noni Juice (Morinda citrifolia) to Prevent Cancer Progression in Mice Induced DMBA and Cigarette Smoke Exposure JF - Pharmacognosy Journal Y1 - 2020 A1 - Didin Wahyu Agustina A1 - Mulya Dwi Wahyuningsih A1 - Sri Widyarti A1 - Aris Soewondo A1 - Hideo Tsuboi A1 - Muhaimin Rifa’i KW - Homeostatic KW - Immunotoxin KW - Inflammation KW - Noni juice KW - Tumor progression AB -

Introduction: Accumulation of polycyclic aromatic hydrocarbons (PAH) in the body commonly lead to degenerative disease such as cancer. This study aims to investigate the potential of Morinda citrifolia to maintain the immune system against toxic exposure. Materials and Methods: This study used Five weeks old male Balb/C mice as animal model. The 7,12-Dimethylbenz(a)anthracene (DMBA) was administrated for six weeks following with 3 days cigarette smoke (CS) exposure then treated with noni juice (M. citrifolia) for two weeks. Experimental animals were divided into six groups. Normal control (N); DMBA+CS; Cisplatin; D1; D2; and D3. Profil of CD4+TNFα+, CD11b+IL6+, CD11b+IFNγ+, CD4+CD25+ IL10+, NK+IL6+ cells was analyzed by flow cytometry and data was analyzed with one-way ANOVA and Post Hoc Tukey HSD test with a significance of p-values < 0.05. Results: This study show that DMBA+CS induction increasing level of CD11b+IL6+, CD4+CD25+ IL-10+ and NK+ IL-6+ meanwhile decreasing CD4+TNFα+significantly (P<0.5) than Normal group. Noni juice in dose 90 mg/Kg BW decrease cytokine pro-inflammation (IL-6 and IFNγ) both in macrophage and NK cell profile significantly (P<0.05). Noni juice in 30 mg/Kg BW could improve the activation CD4+TNFα+ significantly (P<0.05). Noni juice also has efficacy to control T regulator activation to prevent tumor escape. Conclusion: These results suggest that noni juice has anti-cancer potencies by maintain homeostasis of immune system and could be immune herbal supplement.

VL - 12 IS - 5 ER -