@article {1329, title = {The Impact of Sub Acute Administration of Purified Gambier (Uncaria gambir Roxb.) to The Liver and Kidney Functions and its Reversibility on Rats}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {January 2021}, pages = {44-51}, type = {Original Article}, chapter = {44}, abstract = {

Introduction: The impact of sub-acute administration of purified gambier (Uncaria gambir Roxb.) to the liver and kidney function and its reversibility had been studied on rats. Methods: Rats at the aged of 2-3 months and the bodyweight of {\textpm}250 g were treated with water solution of purified gambier at the dose of 5 mg/kg10 and 20 mg/kg for 7 to 14 consecutive days. Plasma ALP, AST activities, creatinine clearance, liver and kidney ratios were determined on the day 1, 7, 14 one week after the doses stopped. All data on each parameter were analyzed using two-way ANOVA followed by Duncan{\textquoteright}s multiple T-test and significance was taken at p\<0.05. Results: The results showed that all parameters was not affected significantly (p\>0.1), except ALT activity and liver organ ratio decreased significantly (p\<0.05). Conclusion: These indicated that purified gambier is relatively non-toxic to the liver and the kidney of the rats at doses of 5-20 mg/kg BW for 14 days.

}, keywords = {ALP, ALT, CrCl, Liver function, Purified gambier, Renal function}, doi = {10.5530/pj.2021.13.7}, author = {Armenia and Dita Permatasari and Lathifah Putri Sinamar and Keke Estera and Almahdy Ahmadin} } @article {233, title = {In-vivo Hepatoprotective Activity of Methanolic Extracts of Sphaeranthus amaranthoides and Oldenlandia umbellate}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {November 2016}, pages = {98-101}, type = {Original Article}, chapter = {98}, abstract = {
Objective: The present study was carried out to evaluate the in vitro hepatoprotective activity of unexploited plants, Sphaeranthus amaranthoides and Oldenlandia umbellate\ on CCl4 induced liver injury, which are indigenous to South India. Methods: in the present study the methanolic extracts from Sphaeranthus amaranthoides and Oldenlandia umbellata were studied against the carbon tetrachloride hepatotoxicity. Results: significant hepatoprotective effect was obtained against carbon tetrachloride induced liver damage as judged from serum marker enzyme activities (SGOT, SGPT, ALT, and TB) and a normal architecture of liver compare to toxic control. Conclusion: the result revealed that methanolic extracts of Sphaeranthus amaranthoides and Oldenlandia umbellata could be useful in preventing CCl4 induced liver injury.
}, keywords = {ALP, CCl4, Hepatoprotective activity, Oldenlandia umbellata, SGOT, SGPT, Sphaeranthus amaranthoides, TB.}, doi = {10.5530/pj.2017.1.16}, author = {Somnath De and Ramalingam Suresh and Akula Murali Sri Sudhakar Babu and Siddabathuni Aneela} }