@article {498, title = {Maltase Inhibitory Activity of Aqueous Extracts of Zingiber officinale Rosc. and Trigonella foenum-graecum Linn.}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {January 2018}, pages = {226-229}, type = {Original Article}, chapter = {226}, abstract = {

Context: An important approach to diabetes treatment involves the regulation of postprandial hyperglycemia by delaying the release of glucose into the bloodstream using inhibitors for carbohydrate digesting enzymes such as maltase. Current synthetic antidiabetic drugs are associated with side effects that have restricted their usage. Antidiabetic plants such as Zingiber officinale and Trigonella foenum-graecum, commonly used as medicinal herbs in India, provide an attractive alternative as a source of maltase inhibitors. Aim: This study aimed to determine maltase inhibitory activity in antidiabetic plants in comparison with that of a synthetic drug, Acarbose, used as a positive control. Study Design: In vitro Enzyme Inhibition Assay. Materials and Methods: Aqueous plant extracts were prepared using rhizome of Z. officinale and leaves of T. foenum-graecum. Varying concentrations of the aqueous plant extract were tested for maltase inhibitory activity using crude yeast maltase enzyme. Statistical Analysis: Unpaired, two tailed t-test was used to detect the significant difference between the mean maltase enzyme activity of the control and that of the test. Results: The aqueous extract of T. foenum-graecum exhibited a higher potent maltase inhibitory activity with IC50 value of 1.05\% as compared to that of the aqueous extract of Z. officinale with IC50 value of 2.13\%. Acarbose showed the highest potency of maltase inhibition with an IC50 value of 0.014\%. Conclusion: Z. officinale and T. foenum-graecum have significant maltase inhibitory activity (p \<0.05). Thus, a contributing factor to the antidiabetic property of the two plants may be attributed to their maltase inhibitory activity.

}, keywords = {Acarbose, Antidiabetic Plants, Maltase Inhibitory Activity, Trigonella foenum-graecum, Zingiber officinale}, doi = {10.5530/pj.2018.2.39}, url = {http://fulltxt.org/article/469}, author = {Janhavi Jatin Damani and Radiya Pacha-Gupta and Nandita Mangalore} } @article {188, title = {Antiobesity activity of Zingiber officinale}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {Oct 2016}, pages = {440-446}, type = {Original Article}, chapter = {440}, abstract = {

Context: Zingiber officinale Roscoe (Zingiberaceae) rhizome, known commonly as ginger is extensively used in Indian traditional system of medicine for treatment of various disorders. The ethanolic Z. officinale extract is reported to have various activity such as antidiabetic, antihyperlipidemic and antioxidant activity in experimental animals. Objective: To evaluate anti-obesity effect of aqueous Z. officinale extract in murine model of high fat diet (HFD)- induced obesity. Materials and Methods: Male Wistar rats fed with HFD (20 g/day/rat, p.o) for a period of 42 days were used to induce obesity. Aqueous Z. officinale extract (20 mg/kg b.w.) administered orally to HFD fed rats from day 8 to 50 days for a period of 42 days. Body weight gain, serum lipids, insulin and leptin parameters were measured. Results: Oral feeding of the aqueous Z. officinale extract (20 mg/kg) to HFD-induced obese rats for a period of 42 days resulted in significant reduction in body weight gain, insulin, leptin, lipids as compared to rats fed HFD alone. Further, the extract also showed significant increase in high density lipoprotein (HDL-C) levels. Discussion and Conclusion: These results show that aqueous Z. officinale extract possess significant anti-obesity potential.

}, keywords = {High-fat diet, Insulin., Leptin, Rat, Zingiber officinale}, doi = {10.5530/pj.2016.5.5}, author = {Iram Nazish and S H Ansari and Poonam Arora and Adil Ahmad} }