@article {2286, title = {Effect of Propofol TIVA Compared Sevoflurane Inhalation Anesthesia on Triglyceride Levels After Elective Craniotomy Surgery}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {May 2024}, pages = {1-5}, type = {Research Article}, chapter = {1}, abstract = {

Background: Propofol TIVA has been shown to be more effective than sevoflurane in craniotomy surgery. Propofol TIVA offers the benefit of giving better brain relaxation during surgery while also being less expensive than sevoflurane. Nonetheless, it is important to highlight that propofol has side effects that should be considered. Large doses and prolonged anesthesia may result in increased triglycerides (lipids) as well as Propofol Infusion Syndrome (PRIS). As part of their investigation into the detrimental effects of propofol, researchers discovered the necessity for controls to avoid confusing the effects of the surgery itself. Therefore, sevoflurane was chosen as the control group to comprehend and analyze the effects of propofol more accurately. Methods: A prospective observational study analysis was conducted on elective craniotomy patients at RSUD Dr. Soetomo from November to December 2023. 52 subjects were divided into two groups, namely the TIVA Propofol and Sevoflurane Inhalation groups. Each group will be examined for preoperative triglyceride levels and postoperative triglyceride levels while already in the ICU. Results: Postoperative triglyceride levels in the Propofol TIVA group were significantly higher. In the comparison test between the two anesthesia methods on triglyceride levels, there was a significant effect in the Propofol TIVA group. In the test of the relationship between the duration of anesthesia in both groups, there was no significant relationship. In the test of the relationship between the total dose of propofol and triglyceride levels, it was found that the greater the dose of propofol used, the higher the increase in triglyceride levels. In the test of the relationship between the total amount of sevoflurane and triglyceride levels, it was found that the greater the dose of sevoflurane used, the greater the decrease in triglyceride levels, which was statistically not significant. Conclusion: TIVA Propofol increases triglyceride levels compared to sevoflurane inhalation in patients undergoing elective craniotomies.

}, keywords = {Craniotomy, Sevoflurane, TIVA propofol, Triglycerides}, doi = {10.5530/pj.2024.16.}, author = {Andika Perdani Somawi and Nancy Margarita Rehatta and Prihatma Kriswidyatomo and Kohar Hari Santoso and Hamzah and Pudji Lestari} } @article {1898, title = {Effect of Bajakah Tea Extract (Spatholobus littoralis Hassk) on High Density Lipoprotein, Triglyceride and Total Cholesterol Levels in Male Wistar Rats}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {December 2022}, pages = {687-691}, type = {Original Article}, chapter = {687}, abstract = {

Hyperlipidemia is the high concentrations of low-density lipoprotein, cholesterol, and triglycerides in the blood. Furthermore, hyperlipidemia has a risk factor for cardiovascular complications through atherosclerosis that triggers coronary heart disease (CHD). Spatholobus littoralis Hassk known as Bajakah tea is a plant with high antioxidant content and acts as an HMG-CoA reductase inhibitor to suppress lipid metabolism disorders, increase HDL levels, and reduce triglycerides and total cholesterol. Experimental and posttest control group design methods were used to obtain 24 male Wistar rats. Furthermore, the experimental animals were randomly divided into 4 groups, namely K1 (normal rats), K2 (hyperlipidemia rats), K3 (hyperlipidemic rats + pirated tea extract dose 9 mg/200gramBW/day), and K4 (hyperlipidemic rats + simvastatin dose 0.18 mg/200 gBW/day). The study was conducted at the Center for Food and Nutrition Studies Laboratory, Gajah Mada University, Yogyakarta. Data levels of HDL, triglycerides, and total cholesterol were analyzed using the One Way Anova test and LSD post hoc to determine between groups. The results showed that an increase in triglyceride and total cholesterol and a decrease in HDL levels in the K2 group compared to the K1. Triglyceride and total cholesterol decreased in groups K3 and K4 compared to K2, and HDL levels increased in groups K3 and K4 compared to K2. Meanwhile, the results of the analysis obtained p value \<0.05. This study concluded that the administration of Bajakah tea extract at a dose of 9 mg/200gram BW/day for 14 days increase HDL, reduce triglyceride and total cholesterol levels (p\<0,05).

}, keywords = {HDL levels, Hyperlipidemia, Pirated tea extract, Total cholesterol., Triglycerides}, doi = {10.5530/pj.2022.14.155}, author = {Sampurna and Andin Putri Aulia and Eka Puji Liashari and Happy Hapsari and Syafrie Sahrul Gibran and Siti Thomas Zulaikhah} }