@article {1689, title = {The Cytotoxicity Study of Lantana camara Linn Essential Oil on HeLa Cancer Cells Line}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {November 2021}, pages = {1498-1501}, type = {Research Article}, chapter = {1498}, abstract = {

Lantana camara Linn (Verbenaceae) is a natural plant that thrives in tropical climates and is relatively easy to cultivate. In Indonesia, this plant is still often considered as a weed. When held, the unpleasant smell and sticky hand make people dislike this plant even though the flowers are diverse. The essential oil was extracted from the leaves of L. camara by hydrodistillation. This study aimed to see how cytotoxic L. camara essential oil was against HeLa carcinoma cells. This research aimed to discover if L. camara essential oil was cytotoxic to HeLa cancer cells. The GC-MS investigation of an essential oil recognized ten compounds; two main constituents of the oil were Caryophyllene (27.65\%) and Germacrene D (23.01\%). The essential oil showed cytotoxicity on HeLa cervical cancer cell lines. The cytotoxic effect of oil was determined using MTT, IC50 values were 44.86 μg/mL + 0.07

}, keywords = {Cervical cancer, Cytotoxicity, HeLa, Hydrodistillation, Lantana camara}, doi = {10.5530/pj.2021.13.190}, author = {Suryati and Dira Hefni and Fatma Sri Wahyuni and Dachriyanus} } @article {127, title = {In vitro Cytotoxicity Studies of Zn (Zinc) Nanoparticles Synthesized from Abutilon indicum L. against Human Cervical Cancer (HeLa) Cell Lines.}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {December 2015}, pages = {127-131}, type = {Original Article}, chapter = {127}, abstract = {

Background: The Zn nanoparticles synthesized from the plant sources are ecofriendly and are potent anticancer agents. Objective: The objective of the present work was to evaluate In vitro cytotoxic activity of Zn nanoparticles green synthezised from Abutilon indicum extract against HeLa cell lines (cervical cancer). Methods: The aqueous extract is prepared by cold extraction (maceration) using water as a solvent. Phytochemical analysis was done by using the standard procedures. Aqueous extract of A. indicum was used for synthesis of Zn nanoparticles. The nanoparticles were characterized by UV-Visible spectrometry and Scanning electron microscopy (SEM) techniques. In vitro cytotoxicity studies of Zn nanoparticles were done by MTT assay using HeLa cell lines. Results: The preliminary phytochemical results revealed that the aqueous extract of A. indicum contains broad spectrum of secondary metabolites like Tannins, Saponins, Glycosides, Flavonoids, Anthroquinones, Terpenoids and Steroids. The U.V spectrophotometeric analysis of Zn nanoparticles displayed maximum absorption at 270 nm and scanning electron microscopic studies showed that the nanoparticles size ranges from 50-500 nm. The MTT assay results revealed that the of Zn nanoparticles exhibits potent cytotoxicity against HeLa cell lines with IC50 value of 45.82 \μg/ml. Conclusion: Thus the present study concludes that Zn nanoparticles can be used as a potent drug in alternative therapy for treating the cervical cancer patients.

}, keywords = {Abutilon indicum, Cervical cancer, Cytotoxicity, MTT Assay, Zn nanoparticles}, doi = {10.5530/pj.2016.2.5}, author = {Badarinath Druvarao Kulkarni and Samim Sultana and Mayuri Bora and Ishita Dutta and Padmaa Milaap Paarakh and Vedamurthy Ankala Basappa.} }