@article {1133, title = {Anti-arthritic Property of Sahacharadi Kashayam Against Freund{\textquoteright}s Complete}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {May2020}, pages = {459-464}, type = {Original Article}, chapter = {459}, abstract = {

Introduction: The available modern molecular drugs for the therapy of Rheumatoid arthritis are beset with several side effects and alternative drugs are urgently needed. The present investigation was performed to evaluate the anti-arthritic activity of Sahacharadi Kashayam (SK), an Ayurvedic formulation, against Freund{\textquoteright}s complete adjuvant (CFA) - induced arthritis in rats. Methods: In this experimental trial, SK was administered at doses of 0.5, 1.0 and 1.5 ml/kg body weight orally to adjuvant (CFA) induced arthritic rats. The anti-arthritic activity was evaluated by using paw volume, haematological parameters and arthritic biomarkers. The efficacy of the Kashayam was compared with the standard Leflunomide (10 mg/kg) drug. Results: Significant reduction in paw volume and thickness by SK (0.5 ml dose) has been found and there was considerably improvement in haematological parameters and arthritic markers in CFA rats till 14 days. After 14th day SK treatment with doses (1.0 and 1.5ml), however, reoccurrence of inflammation and pathological changes were observed in rats. Conclusion: The study clearly indicated the anti-arthritic role of SK. Future studies, however, are warranted to provide a new approach in relation to the therapeutic dose and treatment period of SK which may eventually lead to the development of a new category of the anti-arthritic agent.

}, keywords = {Anti-arthritic activity, Arthritis, Biomarkers, Sahacharadi Kashayam}, doi = {10.5530/pj.2020.12.71 }, author = {P Praveen Kumar and K Prabhu and Mudiganti Ram Krishna Rao and Mallika Jain and K Kalaivani and Shruthi Dinakar and Sampad Shil and N Vijayalakshmi} } @article {803, title = {Effects of Aqueous and Ethanol Root Extracts of Olax subscopioidea on Inflammatory Parameters in Complete Freund{\textquoteright}s Adjuvant-Collagen Type II Induced Arthritic Albino Rats}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {January 2019}, pages = {16-25}, type = {Original Article}, chapter = {16}, abstract = {

Aim/Background: Rural and Urban dwellers in Nigeria claim to treat their arthritis with Olax subscorpioidea root extracts. One of the reasons they chose this treatment is that it is effective and cost less than orthodox drugs with their accompanying side effects. Hence the aim of this study is to investigate the anti-arthritis effects of Olax subscorpioidea Afzel ethanol and aqueous root extracts on chicken type II-Complete Freund{\textquoteright}s adjuvant (CFA) induced arthritis rat model. Materials and Method: The anti-arthritic potential of ethanol and aqueous root extracts of Olax subscorpioidea was evaluated using the chicken type II-Complete Freund{\textquoteright}s adjuvant model in 135 female wistar albino rats. The rats were treated with aqueous and ethanol root extracts of Olax subscorpioidea at varying doses and standard indomethacine drug. Results: The ethanol and aqueous root extracts of Olax subscorpioidea showed significant anti-arthritic activity that was statistically similar to that of indomethacine. Our results suggest that the alcoholic extract of Olax subscorpioidea showed significant (P\<0.05) anti-arthritic potential.

}, keywords = {Adjuvant, Arthritis, Indomethacine, Plant extracts, Rats}, doi = {10.5530/pj.2019.1.4}, author = {Nkiru Nwamaka Ezeani and Udu Ama Ibiam and Obasi Uche Orji and Ikechuku Okorie Igwenyi and Chinyere Aloke and Esther Alum and Partrick Mmaduabuchi Aja and Okechukwu Paul Chima Ugwu} } @article {903, title = {A Review on Ethnobotanical, Phytochemical and Pharmacological Profile of Pinus wallichiana A.B. Jacks}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {July 2019}, pages = {624-631}, type = {Review Article}, chapter = {624}, abstract = {

Introduction: Pinus wallichiana A.B. Jacks. or the blue pine is one of the important conifer that grows all along the Himalayan range from Afghanistan in the west to Myanmar and China in the east covering the Himalayan regions of Pakistan, Nepal and India. It is found in the upper region of the mountains and often remains associated with other gymnosperms. The plant is of immense ethnobotanical relevance and finds extensive use among the people inhabiting the mountainous region. They are primarily valued for its timber and used for construction and infrastructural purposes. Medicinally the plant is very much important. Throughout the Himalayan region the plant is used for the cure of a number of diseases including treatment of fever, cough and cold, bone fracture, healing of injury and wounds, rheumatic pain, arthritis, inflammations etc. The plant is rich in terpenoids and flavonoids all of which possess strong antioxidant properties. Methods: Extensive literature survey was made in the internet with pubmed, google scholar forming the search platform to illustrate the traditional usage of the plant among inhabitants of various regions of Himalayas. Informations of traditional usage, chemical constituents and selected pharmacological activities of the plant were pooled from available research papers to frame the review. Results and Outcome: In this review, an attempt has been made to compile the ethnobotanical usage of Pinus wallichiana, its phytochemistry and pharmacological activity highlighting its potentiality as a cheap and affordable source of drugs for the benefit of population of Indian subcontinent and adjoining areas.

}, keywords = {Antioxidant, Arthritis, Conifer, Flavonoids, Himalaya, Terpenoids}, doi = {10.5530/pj.2019.11.100}, author = {Dwaipayan Sinha} }