@article {1183, title = {Anti-Inflammatory Activity and Quantitative Analysis of Major Compounds of the Mixtures of Derris scandens (DZSS) Formula}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {June 2020}, pages = {828-834}, type = {Research Article}, chapter = {828}, abstract = {

Background: The mixtures of Derris scandens (DZSS) formula is a Thai traditional medicine, which consists of 4 medicinal plants, including Derris scandens (Roxb.) Benth. (D) Zingiber cassumunar Roxb. (Z), Suregada multiflora Baill. (S) and Siphonodon celastrineus (S). The DZSS formula has been used in an oral dosage form for the treatment of muscle pain. However, the phytochemical profiles and the pharmacological activities of the combined DZSS formula have not been clearly investigated. Objective: This study aimed to investigate the phytochemical profiles and the anti-inflammatory activity of the DZSS formula. Materials and Methods: The ethanolic extracts of the formula (50\% and 95\% ethanolic extracts) were prepared by using soxhlet extraction and which were analyzed by using HPLC. The anti-inflammatory activity of the DZSS formula was tested for its inhibitory effect against nitric oxide (NO) production in Raw 264.7 cells macrophage.The cytotoxic effect of the formula was determined by using the MTT assay. Results: The 95\% ethanolic extract of the DZSS formula exhibited a pronounced anti-inflammatory activity with the IC50 of 40.08 {\textpm} 2.78 μg/mL. The 95\% ethanolic extract possessed a more potent anti-inflammatory activity than that of the 50\% ethanolic extract and with no cytotoxicity. HPLC analysis indicated that the 95\% ethanolic extract also had a higher yield of genistein and compound D, which are obtained the amount of 0.71 {\textpm} 0.00 and 18.89 {\textpm} 0.24 mg/g extract, respectively. Conclusion: Our data suggest that the 95\% ethanolic extract of the DZSS formula possessed a significant anti-inflammatory activity but which is still required to investigate about biological activity in vivo and clinical study.

}, keywords = {Anti-inflammatory activity, Compound D, Derris scandens, genistein, HPLC, Nitric Oxide (NO)}, doi = {10.5530/pj.2020.12.119}, author = {Orapan Ayameang and Ruchilak Rattarom and Catheleeya Mekjaruskul and Wanida Caichompoo} } @article {626, title = {Evaluation of Modulatory Effect of Combination of Spondias Pinnata and Whey Preparation on Intestinal Antioxidants and Inflammatory Markers in Etoposide Induced Rat Model for Mucositis}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {June 2018}, pages = {640-644}, type = {Original Article}, chapter = {640}, abstract = {

Background: Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of human cancers. The efficacy of this drug is often limited due to severe sideeffects such as mucositis, anorexia, myelosupperssion, alopecia. At present there are no anti-mucositic agents without side effects. To combat these side effects of cancer treatment, innovative and specific nutritional interventions are needed. The experimental procedure included an oral treatment with combination of Spondias pinnata and whey preparation (100 mg/kg b.w).on etoposide induced mucositis. Methods: Study was conducted at Central Research Laboratory, Kasturba Medical College. Rats were sacrificed by cervical dislocation and duodenum collected for estimation of biochemical parameters. Estimation was carried out for assessing the levels of TAO, GSH, LPO, NO and activity of MPO. Correlation analysis was performed by one-way Anova using graph pad prism to find the relation between control and test. Result: The antioxidant (TAO and GSH) were found to be significantly high in the rats which received the combination compared to the individual Spondias pinnata and whey treated groups. Administration Spondias pinnata and whey in combination shows significant decrease in the TBARS, NO and MPO levels. Conclusion: Spondias pinnata and whey preparation supplementation in combination have shown mucoprotective effects in rat model. Hence it can be considered as anti-mucositis therapeutic agents which can be safely administered during chemotherapy and can reverse mucositis.

}, keywords = {Etoposide, Lipid peroxidation (LPO), Mucositis, Myeloperoxidase (MPO), Nitric Oxide (NO), Spondias pinnata, Whey preparation}, doi = {10.5530/pj.2018.4.105}, url = {http://fulltxt.org/article/643}, author = {Vyshnavi, Gayathri Rao and Shyamala Nayak and Beena Shetty} }