@article {947, title = {The Identification of Bioactive Compounds from Turbinaria ornata (Turner) J. Agaradh and Computational Studies}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {September 2019}, pages = {873-883}, type = {Original Article}, chapter = {873}, abstract = {

Aim/Background: The present work was carried out to identify some of the bioactive components present in the Brown seaweed Turbinaria ornata by GC-MS technique, and to ascertain its medicinal properties. Materials and Methods: GC-MS analysis of some of the potent volatile constituents present in the pet ether of Turbinaria ornata was performed. MD simulations were performed for complex structures of human secretory PLA2 and P38 kinase. GC-MS chromatogram showed peaks indicating the presence of various compounds of interest. The interpretation of the mass spectrum of GC-MS was done using the Database of Indian Institute of Crop Processing Technology (IICPT). Twenty compounds were identified in pet ether extract of Turbinaria ornata. All 20 compounds were screened using PASS online activity prediction server, for the possession of anti-inflammatory potency and the selected target proteins were subjected to molecular docking studies. MD simulations were also performed for the top listed compound 16 which was identified from D3P extract (2,3-Diphenylcyclopropyl)methyl phenyl sulfoxide, trans-). Similarly, the complex structure of PLA2 (phospho-ethanolamine, PE) and P38 kinase (3-(2-pyridine-4-ylethyl)-1H-indole) were simulated for comparative study. Results and Conclusion: Based on the in silico results, the binding affinities for compounds of T. ornata were judged against known standards for its capability to restrain inflammation and to promote possibility for scheming potential antiinflammatory lead from natural compounds were discussed.

}, keywords = {Bioactive components, Brown algae, GC-MS, Molecular docking and simulation studies, T. ornata}, doi = {10.5530/pj.2019.11.140}, author = {S. Deepa and K. Sujatha and D Velmurugan} } @article {438, title = {Laetiporus sulphureus (Bull.: Fr.) Murr. as Food as Medicine}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {November 2017}, pages = {s1-s15}, type = {Review Article}, chapter = {s1}, abstract = {

Laetiporus sulphureus is a sulphur yellow coloured polyporous mushroom and popularly known as \“chicken of the woods\”. Over the generations, this cosmopolitan macrofungus has become an integral part of tribal cuisines particularly for its taste. Besides, it has equal importance in folk medicine being widely used for treatment of pyretic diseases, coughs, gastric cancer and rheumatism. Thus, the species is considered as a natural reservoir of both nourishment as well as drug therapy and consequently it has become increasingly popular in scientific world. Nutritional sciences recently have witnessed it as a sustainable food supply to growing population due to enrichment of carbohydrate (trehalose\> mannitol\> fructose), protein (histidine, isoleucine, leucine, lysine, methionine, threonine), minerals (calcium, phosphorus, magnesium, sodium, potassium, iron, zinc, manganese, copper), vitamins (B, D, E), polyunsaturated fatty acids (linoleic acid, oleic acid, palmitic acid) and fibre. Conversely, the mushroom has also been regarded as an abundant source of chemical compounds including phenolics, triterpenes, polysaccharides with wide range of biological activities such as antiinflammatory, antimicrobial, antioxidant, antihyperglycemic, antitumor and immunomodulation effects. Therefore, a complete summary of the research progress on this fungus is necessary for further studies and commercial exploitation. In this context, the present review attempts to congregate current knowledge on nutritional value, myco-chemistry and therapeutic potential of this culturally important species. However, investigation on bioavailability, quality control, toxicology data and clinical assessment are highly recommended for future research.

}, keywords = {Bioactive components, Commercial Importance, Ethnic Relevance, Nutritious Food, Pharmacological Effects, {\textquotedblleft}Chicken of the Woods{\textquotedblright}}, doi = {10.5530/pj.2017.6s.151}, url = {http://fulltxt.org/article/374}, author = {Somanjana Khatua and Sandipta Ghosh and Krishnendu Acharya} } @article {1452, title = {GC-MS Analysis of Phytocomponents in, Pet Ether Fraction of Wrightia tinctoria Seed.}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {29th Apr, 2015}, pages = {249-253}, type = {Original Article}, chapter = {249}, abstract = {

Introduction:Wrightia tinctoria R.Br. (Family: Apocynaceae) commonly called \“Indrajau\” is well known in Indian traditional system for its traditional uses. Materials and Methods: The present investigation was carried out to determine the possible bioactive components of plant seed ethanolic extract, pet ether fraction using GC-MS analysis. 22 components were identified from pet ether fraction obtained from elution of ethanolic extract packed in silica column. Results: The prevailing compounds from fraction F6to F9 were [1,1\&$\#$39;-Bicyclopropyl]-2-octanoic acid, 2\&$\#$39;-hexyl-, methyl ester (21.39\%) , Trilinolein (7.74\%), 2-Myristynoyl pantetheine (18.07\%), 9-Octadecen-12-ynoic acid, methyl ester (4.46\%), 1Hexadecanol,2-methyl (3.77\%), Cyclopropane tetradecanoic acid, 2-octyl-, methyl ester (2.36\%), 1b, 4a-Epoxy-2H-cyclopenta [3,4] cyclopropa [8,9]cycloundec [1,2-b]oxiren-5 (6H)-one, 7-(acetyloxy) decahydro-2,9,10-trihydroxy-3,6,8,8,10a-pentamethyl (38.91\%), Geranyl isovalerate (23.58\%), cis-13-Octadecenoic acid (5.91\%), Quassin (3.82\%), cis-10-Heptadecenoic acid (3.08\%), 9,12,15-Octadecatrienoic acid 2-phenyl-1, 3-dioxan-5-yl ester (31.50\%), 9,12,15-Octadecatrienoic acid, (Z,Z,Z)-2,3-dihydroxypropyl ester (14.35\%), Cyclopropanebutanoic acid, 2-[ [2-[ [2- [(2-pentylcyclopropyl) methyl] cyclopropyl] methyl] cyclopropyl] methyl]-, methyl ester (10.13\%), 6,9,12,15-Docosatetraenoic acid, methyl ester (3.39\%), 9,12-Octadecadienoic acid, (2-phenyl-1,3-dioxolan-4-yl) methyl ester, trans-( 2.73\%), 9,12-Octadecadienoic acid, (2-phenyl-1,3-dioxolan-4-yl) methyl ester, cis-(4.34\%), Ursodeoxycholic acid (7.14\%), Bufa-20,22-dienolide, 3-(acetyloxy)-14,15-epoxy-16-hydroxy-, (3\á,5\á,15\á,16\á)-(4.75\%), 5H-Cyclopropa [3,4] benz [1,2-e]azulen-5-one, 9a (acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-de cahydro-4a,7b,9-trihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-,[1aR-(1a\à,1b\á,4a\á,7a\à,7b\à,8\à,9\á,9a\à)]-(6.59\%), Docosahexaenoic acid, 1,2,3-propanetriyl ester (10.86\%), Olean-12-ene-3,15,16,21,22,28-hexol, (3\á,15\à,16\à,21\á,22\à)-( 4.40\%) found as the major components. Conclusion: It could be concluded that, Wrightia tinctoria contains various bioactive compounds. So it is recommended as a plant of phytopharmaceutical importance.

Key words: Bioactive components, Ethanolic extract, GC-MS, Indrajau, Wrightia tinctoria.

}, keywords = {Bioactive components, Ethanolic extract, GC-MS, Indrajau, Wrightia tinctoria.}, author = {Rajani Srivastava and Alok Mukerjee and Amita Verma} } @article {62, title = {GC-MS Analysis of Phytocomponents in, Pet Ether Fraction of Wrightia tinctoria Seed}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {Jul-Aug 2015}, pages = {249-253}, type = {Original Article}, chapter = {249}, abstract = {

Introduction: Wrightia tinctoria R.Br. (Family: Apocynaceae) commonly called \“Indrajau\” is well known in Indian traditional system for its traditional uses. Materials and Methods: The present investigation was carried out to determine the possible bioactive components of plant seed ethanolic extract, pet ether fraction using GC-MS analysis. 22 components were identified from pet ether fraction obtained from elution of ethanolic extract packed in silica column. Results: The prevailing compounds from fraction F6to F9 were [1,1\&$\#$39;-Bicyclopropyl]-2-octanoic acid, 2\&$\#$39;-hexyl-, methyl ester (21.39\%) , Trilinolein (7.74\%), 2-Myristynoyl pantetheine (18.07\%), 9-Octadecen-12-ynoic acid, methyl ester (4.46\%), 1Hexadecanol,2-methyl (3.77\%), Cyclopropane tetradecanoic acid, 2-octyl-, methyl ester (2.36\%), 1b, 4a-Epoxy-2H-cyclopenta [3,4] cyclopropa [8,9]cycloundec [1,2-b]oxiren-5 (6H)-one, 7-(acetyloxy) decahydro-2,9,10-trihydroxy-3,6,8,8,10a-pentamethyl (38.91\%), Geranyl isovalerate (23.58\%), cis-13-Octadecenoic acid (5.91\%), Quassin (3.82\%), cis-10-Heptadecenoic acid (3.08\%), 9,12,15-Octadecatrienoic acid 2-phenyl-1, 3-dioxan-5-yl ester (31.50\%), 9,12,15-Octadecatrienoic acid, (Z,Z,Z)-2,3-dihydroxypropyl ester (14.35\%), Cyclopropanebutanoic acid, 2-[ [2-[ [2- [(2-pentylcyclopropyl) methyl] cyclopropyl] methyl] cyclopropyl] methyl]-, methyl ester (10.13\%), 6,9,12,15-Docosatetraenoic acid, methyl ester (3.39\%), 9,12-Octadecadienoic acid, (2-phenyl-1,3-dioxolan-4-yl) methyl ester, trans-( 2.73\%), 9,12-Octadecadienoic acid, (2-phenyl-1,3-dioxolan-4-yl) methyl ester, cis-(4.34\%), Ursodeoxycholic acid (7.14\%), Bufa-20,22-dienolide, 3-(acetyloxy)-14,15-epoxy-16-hydroxy-, (3\á,5\á,15\á,16\á)-(4.75\%), 5H-Cyclopropa [3,4] benz [1,2-e]azulen-5-one, 9a (acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-de cahydro-4a,7b,9-trihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-,[1aR-(1a\à,1b\á,4a\á,7a\à,7b\à,8\à,9\á,9a\à)]-(6.59\%), Docosahexaenoic acid, 1,2,3-propanetriyl ester (10.86\%), Olean-12-ene-3,15,16,21,22,28-hexol, (3\á,15\à,16\à,21\á,22\à)-( 4.40\%) found as the major components. Conclusion: It could be concluded that, Wrightia tinctoria contains various bioactive compounds. So it is recommended as a plant of phytopharmaceutical importance

}, keywords = {Bioactive components, Ethanolic extract, GC-MS, Indrajau, Wrightia tinctoria}, doi = {10.5530/pj.2015.4.7}, author = {Rajani Srivastava and Amita Verma}, editor = {Alok Mukerjee} }