@article {2127, title = {Total Phenolic and Flavonoid Contents, Anti-tyrosinase and Antioxidant Activities of Pachyrhizus erosus Extracts}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {October 2023}, pages = {839-842}, type = {Research Article}, chapter = {839}, abstract = {

Background: The storage roots of Pachyrhizus erosus (PE) have been traditionally used as a skin whitening agent in Indonesia and are also consumed fresh in many Southeast Asian countries, including Thailand. However, research on the biological activities of PE is limited. Objective: This study aimed to measure the total phenolic and flavonoid contents and to test the anti-tyrosinase and antioxidant activities of PE extracts. The Folin-Ciocalteu colorimetric, the Aluminium chloride colorimetric, the DPPH scavenging, and the Dopachrome assays were used for the experiments. Results: The dichloromethane extract had the highest anti-tyrosinase activity (IC50= 2.08 {\textpm} 0.40 mg/mL), total flavonoid content (9.93 {\textpm} 0.02 mg QE/g extract), and antioxidant activity (IC50= 40 {\textpm} 0.02 μg/mL). The largest total phenolic concentration was found in the 80\% ethanol extract, albeit (11.97 {\textpm} 0.55 mg GAE/g extract). Conclusion: Based on its remarkable activities, the dichloromethane extract is recommended for future development in skinlightening products. The study{\textquoteright}s findings conclude that PE extracts may be used as an alternate source of antioxidants and anti-tyrosinase agents

}, keywords = {Anti-tyrosinase, Free radical scavenging., Pachyrhizus erosus, total flavonoid content, total phenolic content}, doi = {10.5530/pj.2023.15.160}, author = {Pornpun Laovachirasuwan and Methin Phadungkit} } @article {1192, title = {The Development of Phyllanthus emblica Extract in Ethosomes for Hair Loss Prevention}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {June 2020}, pages = {905-910}, type = {Research Article}, chapter = {905}, abstract = {

Background: Hair loss is not a serious health problem but leads to decreased self- confidence, personality, and psychological problems. According to Thai traditional medical wisdom, Phyllanthus emblica has the property to prevent hair loss. Ethosomes are a drug delivery system, which can increase drug delivery to deep skin layers and enhance the effectiveness of the active ingredient. Objective: This research aims to develop ethosomes of Phyllanthus emblica extract with beneficial properties. Materials and Methods: Phyllanthus emblica was extracted by a maceration method with 95\% ethanol as a solvent. The total phenolic content of the extracts was determined using the Folin-Ciocalteu method. The antioxidation activity was evaluated by DPPH assay. Ethosomes were formulated by a cold method and their properties were observed. Results: The results showed that the total phenolic content of Phyllanthus emblica extract was 406.37{\textpm}2.39 mg GAE/g extract. The IC50 of antioxidant activity was 7.05{\textpm}0.17 μg/ml. Ethosomes with 0.03\% of Phyllanthus emblica extract, 2\% of soya phosphatidylcholine, and 20\% of ethanol had the highest percentage of entrapment efficiency (65.26\%{\textpm}1.80\%). The ethosomes of Phyllanthus emblica extract was the spherical shape and white colloid. The particle size, polydispersity index, zeta potential, and pH of ethosomes were 0.43{\textpm}0.00 μm, 0.44{\textpm}0.03, -10.40{\textpm}0.28 mV, and 4.06{\textpm}0.03, respectively. Conclusion: The ethosomes of Phyllanthus emblica extract had good properties and area possible alternative product for hair loss prevention.

}, keywords = {Entrapment efficiency, Ethosomes, Phyllanthus emblica}, doi = {10.5530/pj.2020.12.128}, author = {Pornpun Laovachirasuwan and Wutthichart Fuangbangluang and Atchariyaporn Phanichanaphan and Issarapong Nasomroop and Methin Phadungkit} }