@article {1398, title = {Cardioprotective Role of Partharishtam on Isopreterenol Induced Myocardial Infarction in Animal Model}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {March 2021}, pages = {591-595}, type = {Research Article}, chapter = {591}, abstract = {

Myocardial infarction (MI) is one of the key causes of high death rate globally. We report the cardio protective effect of an Ayurvedic polyherbal formulation Partharishtam on isoproterenol induced myocardial infarction on albino rats. Administration of Isoproterenol to normal albino rat triggers MI evident from the significant changes in key biomolecules tested in blood serum and cardiac tissues. The cardio protective role of Partharishtam was compared with a standard medicine, Propranolol on some of the known identifying markers of MI such as, Troponin I and T, creatine phosphokinase serum (CPK-S), creatine phosphokinase myoglobulin isozyme fraction (CPK-MB) and oxidative enzymes like super oxide dismutase (SOD), reduced glutathione (GSH) and catalase. There was an appreciable decrease in the levels of Troponin 1 and T, CPK-S and CPK-MB after the treatment of Partharishtam on Isoproterenol induced MI rats. In vivo anti-oxidative enzyme studies also revealed the increase in the levels of SOD, GSH and catalase to near normalcy after the treatment of Partharishtam in MI rats, which is very much comparable to the commonly used drug Propranolol to treat MI patients. Histopathological analysis confirmed the cardio protective properties of Partharistham in rat model. We did not find any side effects or toxicity of Partharishtam when tested on the normal rats. Thus, polyherbal formulation Partharishtam could be considered as safe medicine for MI.

}, keywords = {Catalase, Creatine phosphokinase, GSH, Isoproterenol, Myocardial Infarction, Partharishtam, Polyherbal, Propranolol, SOD, Troponin I, Troponin T}, doi = {10.5530/pj.2021.13.74}, author = {G. Narayanan and K Prabhu and Anath Bandhu Chaudhury and Mudiganti Ram Krishna Rao and V S Kalai Selvi and N S Muthiah and Sruthi Dinakar} } @article {1133, title = {Anti-arthritic Property of Sahacharadi Kashayam Against Freund{\textquoteright}s Complete}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {May2020}, pages = {459-464}, type = {Original Article}, chapter = {459}, abstract = {

Introduction: The available modern molecular drugs for the therapy of Rheumatoid arthritis are beset with several side effects and alternative drugs are urgently needed. The present investigation was performed to evaluate the anti-arthritic activity of Sahacharadi Kashayam (SK), an Ayurvedic formulation, against Freund{\textquoteright}s complete adjuvant (CFA) - induced arthritis in rats. Methods: In this experimental trial, SK was administered at doses of 0.5, 1.0 and 1.5 ml/kg body weight orally to adjuvant (CFA) induced arthritic rats. The anti-arthritic activity was evaluated by using paw volume, haematological parameters and arthritic biomarkers. The efficacy of the Kashayam was compared with the standard Leflunomide (10 mg/kg) drug. Results: Significant reduction in paw volume and thickness by SK (0.5 ml dose) has been found and there was considerably improvement in haematological parameters and arthritic markers in CFA rats till 14 days. After 14th day SK treatment with doses (1.0 and 1.5ml), however, reoccurrence of inflammation and pathological changes were observed in rats. Conclusion: The study clearly indicated the anti-arthritic role of SK. Future studies, however, are warranted to provide a new approach in relation to the therapeutic dose and treatment period of SK which may eventually lead to the development of a new category of the anti-arthritic agent.

}, keywords = {Anti-arthritic activity, Arthritis, Biomarkers, Sahacharadi Kashayam}, doi = {10.5530/pj.2020.12.71 }, author = {P Praveen Kumar and K Prabhu and Mudiganti Ram Krishna Rao and Mallika Jain and K Kalaivani and Shruthi Dinakar and Sampad Shil and N Vijayalakshmi} } @article {1134, title = {Neuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {May 2020}, pages = {465-472}, type = {Original Article}, chapter = {465}, abstract = {

Introduction: In the management of neurodegenerative and neuropsychiatric diseases, memory loss remains very challenging. Saraswatharishtam (SWRT) is an ayurvedic formulation prescribed for several neurological ailments like acute anxiety, partial memory loss, slurred speech, neuro-degenerative diseases like Parkinson{\textquoteright}s, Alzheimer{\textquoteright}s etc. Methods: Present study explores the possibilities of curative effects of SWRT on Scopolamine induced memory impairment and to compare the effects of commonly used drug Piracetam. Adult Wistar Swiss albino mice were used for this experiment and divided into five different groups for the treatments of the drugs in various combinations. The first group was vehicle treated control while the second group was treated with scopolamine to induce memory impairment. The third groups of animals were treated with Scopolamine where the mice were pretreated with standard neuro-protective drug Piracetam, while the fourth and fifth groups of animals were treated with scopolamine and the animals were pretreated with SWRT at the doses of 200 and 400 mg/kg respectively to compare with the effect of Piracetam. Scopolamine was administered on day eight, only for 45 minutes in all the cases (Group I- Group V). Several neurobehavioral parameters were examined to confirm the neuro-protective effects of SWRT. Results: Saraswatharishtam significantly reversed the memory loss in mice model as revealed from elevated plus maze, radial maze and rectangular maze experiments justifying its neuroprotective potential as observed in usually used synthetic Piracetam. SWRT was found to be nontoxic and very promising antioxidant recorded from acute and chronic toxicological studies. Conclusions: It is suggested that SWRT, could be used as safe and easily available Ayurveda medicine to treat neurological dysfunctions without any side effects. Further translational research is needed to explore its neuro-protective potential.

}, keywords = {Antioxidant, Ayurvedic, Elevated Plus Maze, Neuro-protection, Piracetam, Saraswatharishtam, Scopolamine}, doi = {10.5530/pj.2020.12.72 }, author = {Jai Prabhu and K Prabhu and Anathbandhu Chaudhuri and Mudiganti Ram Krishna Rao and V S Kalai Selvi and T K Balaji and Shruthi Dinakar} } @article {1063, title = {Neuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {February 2020}, pages = {6-13}, type = {Original Article}, chapter = {6}, abstract = {

Introduction: In the management of neurodegenerative and neuropsychiatric diseases, memory loss remains very challenging. Saraswatharishtam (SWRT) is an ayurvedic formulation prescribed for several neurological illnesses like acute anxiety, partial memory loss, slurred speech, neuro degenerative diseases like Parkinson{\textquoteright}s, Alzheimer{\textquoteright}s etc. Methods: Present study explores the possibilities of curative effects of SWRT on Scopolamine induced memory impairment and to compare the effects of commonly used drug piracetam. Adult Wistar Swiss albino mice were used for this experiment and divided into five different groups for the treatments of the drugs in various combinations. The first group was vehicle treated control while the second group was treated with scopolamine to induce memory impairment. The third group of animals were treated with Scopolamine where the mice were pretreated with standard neuroprotective drug Piracetam, while the fourth and fifth group of animals were treated with scopolamine and the animals were pretreated with SWRT at the doses of 200 and 400 mg/kg respectively to compare with the effect of Piracetam. Scopolamine was administered on day eight, only for 45 minutes in all the cases (Group I- Group V). Several neurobehavioral parameters were examined to confirm the neuroprotective effects of SWRT. Results: Saraswatharishtam significantly reversed the memory loss in mice model revealed from elevated plus maze, radial maze and rectangular maze experiments justifying its neuroprotective potential as observed in usually used synthetic Piracetam. SWRT was found to be nontoxic and very promising antioxidant recorded from acute and chronic toxicological studies. Conclusions: It is suggested that SWRT, could be used as safe and easily available Ayurveda medicine to treat neurological dysfunctions without any side effects. Further translational research is needed to explore its neuro-protective potential.

}, keywords = {Antioxidant, Ayurvedic medicine, Elevated Plus Maze, Neuroprotection, Piracetam, Saraswatharishtam, Scopolamine}, doi = {10.5530/pj.2020.12.2}, author = {Jai Prabhu and K Prabhu and Anathbandhu Chaudhuri and Mudiganti Ram Krishna Rao and VS Kalai Selvi and TK Balaji and Sruthi Dinakar} }