@article {1003, title = {Chemical Constituents and Anti-Ulcer Activity of Ethylacetate Extract of the Leaves of Sanchezia nobilis Hook.F.}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {October 2019}, pages = {1172-1180}, type = {Original Article}, chapter = {1172}, abstract = {

Study have two objectives. First objective is about the identification of the five components. The second objective is about the antiulcer activity of the ethylacetate extract. Five compounds (1{\textendash}5) were isolated from the leaves of Sanchezia nobilis Hook.F. collected in Nam Dinh province by chromatographic methods. These compounds were identified as: Quercetin (1), Scopoletin (2), Kaempferol-3-O-α-L-rhamnopyranosyl-(1{\textrightarrow}6)-β-D-glucopyranoside (3), Quercetin-3-O-α-L-rhamnosyl-(1{\textrightarrow}6)-β-D-glucopyranosyl-(1{\textrightarrow}3)-β-D-glucopyranoside (4),3{\textquoteright}-Omethyl- 3,4-methylenedioxy ellagic acid (5).Their structures were elucidated by spectroscopic methods, including mass spectrometry (MS) and nuclear magnetic resonance (NMR). Compounds 3, 4, 5 were isolated from the leaves of Sanchezia nobilis Hook.F. for the first time. Evaluation the effect of gastric and duodenal anti-ulcer on cyteamine induced gastric ulcer models indicates at this ethylacetate extract has the effect to improve the extent of ulcer lesions treatment (54,17 \%); obviously reduced the average of number pocket of ulcers (1,85 {\textpm} 0,80) and ulcer index (5,61 {\textpm} 2,69), however, it does not change the area of the ulcer.

}, keywords = {Anti-ulcer activity, Quercetin, Sanchezia nobilis, Scopoletin}, doi = {10.5530/pj.2019.11.182}, author = {Loi Vu Duc and Xuan Bui Thi and Ngoc Tran Minh} }