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Role of Melia azedarach leaf extract in Paracetamol Induced Hepatic damage in rats

Article Metadata
Article Section: 
Pharmacological Studies
Author(s): 
Mohammed Fazil Ahmed, A. Srinivasa Rao, Hameed Thayyil, Shaik Rasheed Ahemad and Mohammed Ibrahim
Abstract: 

The hepataprotective activity of the methanolic leaf extract of Melia azedarach was investigated against paracetamol induced hepatic damage in rats. Over dosing of paracetamol to rats is reported to decrease the activity of antioxidative enzymes (GPx, GST, SOD and CAT ) in liver and increase the serum enzymes (SGOT , SGPT and Alkaline phosphate), bilirubin and decrease the total proteins content. Melia azedarach leaf extract maintained the activity of antioxidant enzymes and as well as serum enzymes to the normal level. Thus the present study ascertains that the leaf extract of Melia azedarach possesses significant hepatoprotective activity.

DOI: 
10.5530/pj.2011.21.10
Keywords: 
Hepatoprotective, Hepatic damage, Methanolic leaf extract, Melia azedarach, Serum enzymes and Antioxidant enzymes
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